TMS Therapy: An Effective Option When Medication Isn’t Enough

The Albany Clinic • January 23, 2026
Quick Summary / TL;DR
TMS therapy is a noninvasive, FDA-cleared option for depression—especially when medication and talk therapy haven’t provided enough relief.
What it is
Magnetic pulses stimulate underactive mood pathways (left prefrontal cortex).
Who it’s for
Often considered after 2+ antidepressant trials or when side effects are a barrier.
Typical outcomes
In TRD, studies often report ~50–55% response and ~30–35% remission.
Time commitment
Usually 20–40 minutes/session, multiple days/week, over ~4–9 weeks.
Depression is one of the most common and disabling mental health conditions, and while many people benefit from first-line treatments like antidepressants and psychotherapy, a significant number continue to struggle with persistent symptoms.
Treatment-resistant depression, or TRD, can leave individuals feeling stuck and discouraged. Fortunately, clinical advancements like TMS therapy have broadened treatment options for those struggling with depression.
TMS therapy for depression offers a promising alternative for people who haven’t achieved adequate relief from medications alone. It represents a meaningful shift in how we address depression when standard treatments aren’t enough.
What Is TMS Therapy?
Transcranial magnetic stimulation (TMS) is an FDA-approved, noninvasive depression treatment that uses magnetic fields to influence the brain regions involved in mood and emotional regulation.
In simple terms, here’s how TMS works: a specialized coil is placed against the scalp and delivers brief electromagnetic pulses that stimulate neurons in the dorsolateral prefrontal cortex. This brain region is known to be underactive in people with depression.
Because the magnetic pulses are delivered externally and do not require surgery or sedation, TMS is performed on an outpatient basis and allows patients to resume their day immediately afterward. There’s no anesthesia, no cognitive side effects, and the vast majority of individuals tolerate treatment extremely well.
TMS promotes neuroplasticity, enhances neurotransmitter activity, and helps normalize dysfunctional brain circuits associated with low mood. It may even encourage the release of serotonin and other neurochemicals tied to emotional well-being. The result is a targeted, medication-free option that can meaningfully support recovery for people living with depression.

How Effective Is TMS Therapy for Depression?
Decades of research demonstrate that for individuals with treatment-resistant depression, TMS consistently delivers meaningful improvement, with response rates hovering around 50–55% and remission rates of roughly 30–35%. These numbers align with broader clinical observations showing that about half of patients who do not improve with antidepressants still experience significant relief through TMS therapy.
A recent consensus review reinforces these findings and highlights TMS as both safe and effective, particularly for treatment-resistant cases. Real-world data from UCLA adds another layer of confidence. When researchers examined outcomes from more than 700 patients, 54% showed clinical response, and many began noticing improvements as early as the first treatment week. These results position TMS as a legitimate neuromodulation therapy for depression.
TMS has come a long way since its early development, culminating in FDA approval in 2008 after major randomized trials confirmed both safety and therapeutic benefit. Since then, ongoing studies continue to validate TMS results for depression, making it one of the most promising tools available for difficult-to-treat depression.
Who Might Benefit from TMS Therapy?
While TMS can be used in a variety of clinical scenarios, TMS therapy for depression may be appropriate for people who:
- Have tried two or more antidepressants without improvement
- Experience significant medication side effects
- Prefer a non-drug, noninvasive treatment approach
However, TMS is not suitable for everyone. Safety factors, such as having magnetic-sensitive implants, a seizure history, or certain neurological conditions, must be evaluated before treatment begins.
Ultimately, determining candidacy for TMS requires a clinical review by a licensed professional, but for many, it represents a meaningful next step when medication alone isn’t enough.
Am I a Candidate for TMS?
A quick checklist to help readers self-identify—final eligibility is confirmed by clinical screening.
Good fit if you…
- Have tried 2+ antidepressants without enough improvement
- Prefer a non-drug, noninvasive option
- Have had side effects with medications
- Want a treatment that doesn’t require sedation or downtime
Screening matters if you…
- Have metal/magnetic-sensitive implants in/near the head
- Have a seizure history or neurological condition
- Are unsure about medication interactions or diagnoses
- Need a plan for ongoing support alongside treatment
What to Expect During TMS Treatment for Depression
Understanding what to expect during TMS treatment can make the entire process feel far more approachable. Sessions take place in a comfortable outpatient setting, and there’s no anesthesia or recovery period. You remain awake, alert, and able to resume normal activities immediately afterward. Treatments are typically scheduled multiple days a week, with each session lasting about 20–40 minutes, depending on the protocol.
Results emerge gradually, which is important to keep in mind. Many patients notice subtle shifts like better sleep, increased energy, or improved focus within the first one to two weeks. By weeks two to four, these changes often become more obvious. Interestingly, the previously mentioned research from UCLA indicates that early improvement within the first several sessions may help predict overall treatment response.
Most treatment courses last between four and nine weeks, and some individuals may choose occasional maintenance sessions afterward to sustain their progress. At The Albany Clinic, we deliver personalized TMS therapy for depression with careful monitoring and an experienced team. We support our patients every step of the way.
Safety and Side Effects of TMS Therapy
When considering any medical treatment, safety matters. And TMS performs well on that front. TMS is generally well tolerated, with most patients experiencing no significant side effects.
The most common side effects are mild: headache or scalp discomfort during or shortly after a session. For the vast majority of people, these symptoms fade quickly.
More serious risks, such as seizures, are rare and typically limited to individuals with known neurological vulnerabilities, which is why proper screening before starting treatment is essential.
How TMS Compares to Other Treatments
Compared to medications like antidepressants, TMS has a distinct advantage. It does not cause systemic side effects sometimes associated with SSRIs and SNRIs, like weight gain, sexual dysfunction, or emotional blunting.
It is also quite different from electroconvulsive therapy (ECT). Unlike ECT, TMS requires no anesthesia, involves no induced seizures, and does not carry cognitive or memory side effects commonly seen in ECT patients.
Why Consider TMS Therapy for Depression at The Albany Clinic?
Choosing where to receive care matters, especially when you’re exploring options beyond standard medication. TMS therapy in Carbondale, IL, at The Albany Clinic is built around evidence-based protocols and personalized treatment plans that reflect each patient’s symptoms, goals, and prior treatment history.
Our clinical team uses careful monitoring throughout the treatment course. We also understand that navigating insurance can be overwhelming, which is why we provide support to help patients understand coverage, benefits, and any out-of-pocket responsibilities.
For individuals who haven’t found relief with antidepressants, or who simply need a well-tolerated, non-medication alternative, we offer a thoughtful and patient-centered path forward.
If you’re wondering whether TMS therapy could help you or someone you care about, we’re here to talk. Request a consultation with us today to learn whether TMS is right for you.
Common Questions About TMS
Quick answers that reinforce safety, expectations, and next steps.
Does TMS hurt?
Can I drive myself home afterward?
How soon will I notice changes?
Who should not get TMS?
Will insurance cover TMS?
Request a consultation and we’ll review candidacy, protocol options, and insurance steps.






