The Immediate & Lasting Power of Spravato for PTSD and TRD

The Immediate & Lasting Power of Spravato for PTSD and TRD

The Albany Clinic • March 14, 2024

In the realm of mental health treatment, especially for Post-Traumatic Stress Disorder (PTSD) and Treatment-Resistant Depression (TRD), the emergence of innovative and effective solutions is always a cause for celebration. The introduction of a new service that has the potential to significantly impact the lives of individuals battling major depression marks a significant milestone in the field of psychiatry. In this article, we'll explore the background on depression and PTSD while introducing Spravato® as a innovative treatment option.

Background on Depression and PTSD

Major depression is a complex and debilitating condition that affects millions of individuals worldwide. Shockingly, between 20% to 70% of Americans diagnosed with major depression may experience treatment-resistant depression after failing at least two adequate trials of antidepressant medication. This staggering statistic highlights the urgent need for alternative and more effective treatment options.

Spravato®: An Innovation in Depression and PTSD Treatment

One groundbreaking solution that has garnered attention since its FDA approval in 2019 is Spravato® (esketamine) nasal spray. This innovative medication has shown promising results during clinical trials in rapidly bringing relief of depressive symptoms to patients grappling with major depression, including those experiencing suicidal thoughts. Furthermore, in clinical trials it has been proven that when combined with an oral antidepressant patients experienced significantly longer relief. The ability of Spravato® to provide swift, substantial, and long-lasting alleviation from depressive symptoms is a game-changer in the realm of mental health treatment.

The Eskatmine Difference

As a nasal spray derived from ketamine, esketamine offers an evidenced based treatment option for patients who have not found relief from traditional antidepressants. Unlike its precursor, ketamine which is administered intravenously, esketamine is administered nasally through a spray. This targeted approach allows for lower dosages, reducing potential side effects. Notably, it can rapidly alleviate symptoms, including suicidal ideation—a vital benefit highlighted by Johns Hopkins Medicine. This novel treatment requires administration under medical supervision due to initial side effects, emphasizing its safe and controlled use.

If you feel treatment for depression isn’t working, talk to your psychiatrist to see if esketamine therapy is an option for you. If you're local to Carbondale Illinois, we can help!

What qualifies you for SPRAVATO®?

Spravato®, a treatment for those with severe depression not responding to conventional medications, is covered by most major insurance policies and designed for medicinal use, distinctly from its ketamine counterpart. It's important to dispel misinformation about Spravato® and ketamine, recognizing Spravato's role in treating depression effectively. However, it's not suitable for everyone, especially individuals with cardiovascular issues or a history of substance abuse, due to risks associated with blood pressure elevation and potential for misuse.


A few other risk factors must be taken into consideration so be sure to tell your provider if you have heart, brain or liver problems, you have ever had psychosis (see, feel, or hear things that aren't there, or believe in things that aren't true), or if you are pregnant or breastfeeding. All prescription or over-the-counter medicines, including vitamins or herbal supplements, must be disclosed to your healthcare professional.


At your appointment your healthcare professional will discuss common side effects with you before deciding if Spravato® is right for you in treating your symptoms of depression.

Clinical Trials and Studies on Spravato®

» Swift Delivery

What sets Spravato® apart from traditional oral antidepressant medications is its unique mode of administration. As a nasal spray, Spravato® bypasses the digestive system and is directly absorbed into the bloodstream through the nasal mucosa. This alternative route of delivery allows for faster onset of action and more targeted delivery of the medication to the brain, resulting in quicker relief for patients in distress.


» Enhanced Access to Life-Saving Medication

Albany Clinic's commitment to providing greater access to Spravato® is a testament to our dedication to improving mental health care. By offering this potentially life-saving medication to patients in need, we are bridging the gap for individuals whose depressive disorder has not responded to conventional treatment methods. The impact of this increased accessibility cannot be overstated in the realm of mental health treatment.


» Future Directions for Spravato® in Depression and PTSD Treatment

Further supporting this breakthrough treatment option, in March 2024 the UConn Health Department of Psychiatry launched a new eskatemine service which represents a significant opportunity to contribute to the scientific literature surrounding this new medicine. Through research, clinical trials, and scholarly collaborations, UConn Health aims to expand understanding of the efficacy and potential applications of Spravato®, paving the way for future advancements in the field of mental health treatment.

Clinical Trials and Studies on Spravato®

Curious about how esketamine service works? Let's dive in and explore the process step by step.


» The Nasal Spray Administration

Once your physician has determined you meet the criteria for esketamine treatment they will administer the nasal spray. Each patient at Albany Clinic is carefully attended to by their treating provider. The nasal spray is expertly administered in the office to ensure the safety and comfort of every individual undergoing treatment.


» Treatment Schedule

Patients receiving esketamine follow a customized treatment schedule. Initially, patients may receive the nasal spray frequently. Following this intensive phase, the frequency of administration may reduced based on results in reducing depressive symptoms. This structured approach aims to optimize the therapeutic benefits of esketamine for patients and help to reduce common side effects.


» Continuation of Treatment

After the initial period of treatment, patients may continue receiving esketamine on a less frequent basis based on an assessment by their provider. This flexibility allows for personalized treatment plans tailored to each individual's needs. Qualified providers at The Albany Clinic work closely with patients to determine the most effective and sustainable long-term treatment strategy.


» The Powerful Potential of Combining Esketamine Treatment with Therapy

One of the most promising avenues in mental health treatment for depressive disorders such as PTSD and TRD involves the fusion of esketamine with therapy and oral antidepressants. When combined with therapy, such as cognitive-behavioral therapy (CBT) or psychotherapy, esketamine treatment can potentially enhance the overall efficacy of treatment by addressing both the biological and psychological aspects of depression.

The synergistic effect of esketamine and therapy holds the promise of not just alleviating symptoms but also addressing the underlying causes of depression, leading to more sustainable and long-term recovery outcomes for individuals battling treatment-resistant depression.

the word spravato is on a white background

Conclusion & Support

As we look ahead to the future of mental health treatment, the emergence of new services that combine esketamine treatment with traditional therapies offers a dual ability to contribute to the treatment of post-traumatic stress disorder and treatment resistant depression. By integrating cutting-edge pharmacological interventions with evidence-based psychological approaches, these services have the potential to address the complex and multifaceted nature of depression more comprehensively.


Furthermore, by grounding their practice in the evidence base that guides the mental health field, these innovative services not only provide clinical benefits to individuals seeking relief from depression but also contribute to the advancement of scientific knowledge and best practices in mental health care.


Together, the collaborative efforts of researchers, clinicians, and institutions like UConn School of Medicine and John Hopkins Medicine pave the way for clinics like The Albany Clinic to envision a future where individuals with treatment-resistant depression have access to more effective and holistic treatment options that promote healing and recovery.


Seeking Help for Severe Depression or Suicidal Thoughts

Struggling with severe depression or suicidal thoughts is an urgent matter that requires immediate attention and care. If you or someone you know is in crisis, it's essential to take action to ensure safety and well-being.


Alert Your Psychiatric Provider Immediately

If you have a psychiatric provider or therapist, let them know about your current state as soon as possible. They can offer support, guidance, and even make adjustments to your treatment plan to provide you with the help you need.


Get Help by Calling 9-1-1, 2-1-1, or the National Suicide & Crisis Hotline 988

If you do not have a psychiatric provider or if the situation is urgent, do not hesitate to reach out for help immediately. You can call emergency services by dialing 9-1-1, contact a local crisis helpline such as 2-1-1, or connect with the National Suicide & Crisis Hotline by dialing 988. These resources are available 24/7 to provide support and assistance during times of crisis.


The Albany Clinic in Carbondale Illinois invites you to
reach out for expert guidance and support on your journey towards healing and stability. We offer Spravato® treatment as well as traditional ketamine infusion, TMS therapy, and other services to help with depression.

35 Albany Rd. Suite A Carbondale, IL 62903

Phone:     (888) 804-4330

Source:

Daly, Ella J et al. “Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.” JAMA psychiatry vol. 76,9 (2019): 893-903. doi:10.1001/jamapsychiatry.2019.1189

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Living with post-traumatic stress disorder (PTSD) can be debilitating. Nightmares, flashbacks, and a constant sense of being “on edge” can interfere with work, relationships, and overall quality of life. If you’ve tried therapy or medications without lasting relief, you’re not alone—and there may be another option. At the Albany Clinic in Carbondale, Illinois, we specialize in ketamine therapy as a promising treatment for PTSD. Understanding PTSD Post-traumatic stress disorder (PTSD) develops after experiencing or witnessing trauma. While everyone responds to trauma differently, common symptoms include: Intrusive memories or flashbacks Avoidance of reminders of the trauma Emotional numbness or detachment Heightened anxiety , irritability , or trouble sleeping Some people also develop complex PTSD (CPTSD) , which stems from repeated or prolonged trauma. CPTSD often comes with additional challenges, such as difficulty regulating emotions or maintaining healthy relationships. Current Treatments and Their Limitations The most common treatments for PTSD include cognitive behavioral therapy (CBT) , eye movement desensitization and reprocessing (EMDR) , and antidepressant medications . For many people, these treatments can be helpful. However, they also come with challenges: Medications may take weeks to work and don’t help everyone. Therapy can take months or years to create lasting change. Therapies can be difficult to engage with, as they involve discussing the trauma, which can be distressing or may cause someone to shut down emotionally. Some individuals continue to experience severe symptoms despite treatment. This is where ketamine therapy offers a new avenue of hope. How Ketamine May Help PTSD Ketamine works differently from traditional antidepressants. Instead of gradually altering brain chemistry, ketamine acts quickly on key brain circuits involved in mood and fear. Rebalancing brain activity : Ketamine boosts activity in the prefrontal cortex , the part of the brain that helps regulate emotions. It also decreases activity in the amygdala , the brain’s fear center, helping reduce anxiety and hypervigilance. Promoting neuroplasticity : Ketamine encourages new connections between brain areas, helping “rewire” pathways associated with PTSD symptoms. Supporting fear extinction : Ketamine supports fear extinction, the process by which the brain ‘unlearns’ fearful responses to things it expects to be threatening. This is especially important in PTSD, where people may react to safe situations or cues as if they were actual threats. Benefits of Ketamine for PTSD Research continues to grow, but studies and clinical experience have shown several promising benefits: Rapid relief : Many patients notice improvements within hours to days, rather than weeks. This can be especially important during a mental health crisis or for those struggling with suicidal thoughts. Effective when other treatments have failed : Ketamine can offer relief even for people who haven’t responded to medications or therapy. Sustained improvement : With a series of treatments, many patients experience lasting relief from PTSD symptoms. Increases the benefits of other therapies : Ketamine may speed up the outcomes of other trauma-based therapies, such as prolonged exposure therapy . In a 2021 study , people with severe PTSD received either ketamine or a comparison drug over two weeks. Those given ketamine showed much faster and greater improvement in PTSD and depression symptoms. About 67% had significantly improved symptoms , with the biggest differences in intrusive memories, avoidance, and negative thoughts and mood. The treatment was also well-tolerated with few adverse effects. Ketamine Treatment for PTSD at the Albany Clinic At the Albany Clinic in Carbondale, Illinois, we are dedicated to providing safe, effective ketamine therapy for people with PTSD and other psychiatric disorders. We administer ketamine intravenously to support a rapid reduction in symptoms. Here’s what you can expect: A thorough medical and psychiatric evaluation before treatment begins Comfortable, private treatment rooms Careful monitoring by experienced medical professionals throughout each session A personalized treatment plan designed around your needs During your treatment, you’ll have a small plastic catheter inserted into a vein in your arm, which will deliver ketamine straight into your bloodstream. You may experience mild side effects, such as dizziness and dissociation , which can make you feel disconnected from your body and the world around you. These typically wear off after the session is finished. The infusion takes 45 minutes to one hour , and you’ll be closely monitored by staff during the infusion and afterwards to ensure your safety. We’ll provide you with guidance on aftercare once you’re done and how to make the most of your new headspace. Most people with PTSD require multiple infusions to experience sustained, meaningful changes. However, the treatment plan will be tailored according to your unique needs. Get in Touch Today If you or a loved one is struggling with PTSD and current treatments haven’t provided the relief you need, ketamine therapy may be an option worth exploring. At the Albany Clinic, we are here to answer your questions and guide you through every step of the process. Get in touch to find out more.