A Guide to IV Ketamine

A Guide to IV Ketamine

Matt Rodriguez • July 8, 2025

Intravenous (IV) ketamine has emerged as a promising option for individuals struggling with treatment-resistant depression and other hard-to-treat mental health conditions. Ketamine was originally developed as an anesthetic, but is now being used in controlled medical settings to deliver rapid relief when traditional therapies fall short. This guide explores the history, science, benefits, and practical considerations of IV ketamine therapy and what you can expect from treatment at The Albany Clinic.

History of IV Ketamine Therapy

Ketamine was first developed in 1962 as an anesthetic for surgery. It was initially used in veterinary anesthesia, and soon became approved for human use in the form of ketamine hydrochloride, sold under the name Ketalar. The FDA approved ketamine in 1970, and the medication was used extensively among soldiers during the Vietnam War.

In the 1990s and early 2000s, researchers began studying how ketamine affects mood. They saw that small doses could ease symptoms of depression within hours, even in people who didn’t get better with standard antidepressants. Numerous clinical trials have since demonstrated ketamine’s powerful ability to help treat depression and other mental health disorders. 

Today, doctors still use ketamine for anesthesia in hospitals, but some clinics also use it off-label to treat mental health conditions. Off-label means the FDA hasn’t approved it for those uses, but doctors can still prescribe it when supported by research and medical judgment. 

What Are Ketamine Infusions?

Ketamine infusions are a form of treatment where ketamine is delivered directly into a patient’s bloodstream through an intravenous (IV) injection. 

During an infusion, a nurse or doctor inserts a small needle into a vein in the patient’s arm. The ketamine flows slowly from a bag or syringe through a tube into your bloodstream, where it rapidly travels to the brain and elicits an effect. Many people feel these effects within a matter of hours. 

Other methods of ketamine administration include oral tablets and nasal sprays, but IV infusions are the most well-researched. They’re most commonly used in mental health settings due to their steady absorption, quick onset of action, and predictable results

How IV Ketamine Works in the Brain

Ketamine works in the brain by blocking NMDA receptors, proteins that respond to a chemical called glutamate. By blocking specific types of NMDA receptors, ketamine increases the action of glutamate, which increases chemical signaling in the brain. Brain activity increases in areas associated with mood and emotions, like the prefrontal cortex (PFC), which may partly explain the rapid antidepressant effects.

Ketamine also increases neuroplasticity, the brain’s ability to reorganize itself. This helps with depression in three main ways:

  • Synaptic plasticity is the reorganization of synapses, which are junctions where nerve cells communicate. This mechanism may strengthen nerve circuits associated with mood and regulation. 
  • Neurogenesis - the process of generating new nerve cells. This mechanism could restore damage associated with depression. 
  • Functional connectivity is how different brain regions interact. It allows people to more easily “break free” from negative thought cycles and gain new perspectives. 

Ketamine also lowers inflammation, the body’s natural defense system. Chronic inflammation can cause damage to brain areas and worsen symptoms of depression, anxiety, and fatigue. 

Conditions Treated with IV Ketamine

At The Albany Clinic, IV ketamine is used mainly for treatment-resistant depression (TRD). This disorder is when people have continued severe depression symptoms, despite trying at least two standard medications for at least six months. 

Clinical studies show that ketamine can have rapid-acting, significant benefits for people with TRD.  A trial showed that 55% of patients with TRD and major depressive disorder (MDD) had a substantial improvement in symptoms following a three-week treatment course of IV ketamine. 

As well as depression, IV ketamine can also help with:

Doctors usually recommend IV ketamine after other treatments have failed.

What to Expect During IV Ketamine Treatment

If you’re interested in IV ketamine in Illinois, here’s what you can expect from treatment at the Albany Clinic in Carbondale. 

Medial Evaluation

Your treatment begins with a full medical evaluation to decide if ketamine is safe for you. At The Albany Clinic, you meet with our expert physician, Dr. Garwin, who will review your health history, medications, and symptoms.

In-Clinic Treatment

Each session lasts about 45 minutes. You sit or lie down in a quiet room while the medication flows through an IV into your arm. Our staff will monitor you during the infusion to ensure your safety. In most cases, you will be able to leave within 30 to 45 minutes at the conclusion of the procedure.

During treatment, you may feel:

  • Light-headed
  • Drowsy
  • Calm
  • Detached from your surroundings
  • A floating sensation

Most people return to normal within an hour or two. You cannot drive afterward, so someone must take you home. 

Ongoing Treatments

In the days following your initial treatment, you’ll have a follow-up meeting with Dr. Garwin, who will determine whether you need to schedule a subsequent appointment. A typical plan includes 6 to 8 infusions over two to four weeks, varying on your unique needs and treatment response.
 

Risks and Safety of IV Ketamine Therapy

Ketamine is generally safe when given in a clinical setting. However, like all treatments, it has side effects and risks. Common short-term side effects include:

  • Nausea
  • Dizziness
  • Confusion
  • Blurred vision
  • Increased blood pressure

These effects usually go away soon after the session. Drinking water and resting afterward may help.

Long-term use of high-dose ketamine can harm the bladder or lead to dependency. That’s why clinics like The Albany Clinic follow strict dosing rules and monitor your progress closely.

You should not receive IV ketamine if you have:

  • Uncontrolled high blood pressure
  • Active psychosis or mania
  • History of substance misuse
  • Unstable heart disease
  • Pregnancy or breastfeeding

Our team performs a thorough evaluation to keep you safe. We review your health and answer your questions before starting treatment.

How Much Does IV Ketamine Cost?

Ketamine used for mood or pain disorders is not FDA-approved for those uses. Because of this, insurance usually does not cover IV ketamine.

At The Albany Clinic, each infusion costs $500, payable at the time of your visit. This price is on the lower end compared to other ketamine clinics in Illinois. Many people find the cost worthwhile due to the rapid relief that ketamine may offer.

If the price is too high, ask about Spravato (esketamine), a form of ketamine that is covered by most insurance plans. Spravato is a nasal spray version of ketamine, which is approved specifically for TRD and MDD with suicidality.

IV Ketamine for Depression in Illinois

The Albany Clinic is a trusted provider of IV ketamine therapy in Carbondale, Illinois, focusing on helping people with difficult-to-treat mental health disorders. Our clinic offers private treatment rooms, advanced medical equipment, and a caring team of professionals. Each plan is built around your needs and safety.

If other treatments haven’t worked, IV ketamine may offer a new path forward.

Key Takeaways

  • Ketamine began as an anesthetic and now supports treatment for depression and many other mental health disorders.
  • IV ketamine has significant, rapid-acting antidepressant effects, even when other medications fail. 
  • Ketamine works by increasing the activity of glutamate and promoting neuroplasticity. 
  • Ketamine has side effects and isn’t suitable for all patients because of its risks. 
  • Sessions cost $500 each at The Albany Clinic, but we also provide Spravato as a more affordable alternative.


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